If the intervention is a direct response to the diagnosis, the outcome is the intended effect of the intervention. Remember, you don't know until you do research the effect of a particular intervention on a patient population. That's why you're doing research in the first place!
So the (O) in PICO is an outcome you want to find or a likely outcome you think you might find.
Problem: Adults with schizophrenia are struggling to graduate from college
|P||Adults with Schizophrenia|
|C||No supported education|
|O||Higher graduation rates